"A couple of years ago when we started to perform head-fixed chronic recordings in developing mice for another project, we recognized that activity within layer 2/3 of the medial prefrontal cortex ...

To achieve goals in a dynamic environment, the prefrontal cortex (PFC) facilitates various cognitive functions that allow an organism to detect and discriminate information, identify changes in ...

A brain structure called the amygdala, and its connections with another region, the prefrontal cortex, shape people’s experiences and social interactions. The discovery of a key molecular mechanism ...

Neuronal sequences in the medial prefrontal cortex of the brain encode critical information associated with a procedural rule. These sequences can be explored and leveraged as novel biomarkers for ...

This schematic outlines their analytical framework. The approach involves creating a validated developmental atlas of the dorsal prefrontal cortex from structural connectivity, then using these ...

A UCLA-led study has provided an unprecedented look at how gene regulation evolves during human brain development, showing how the 3D structure of chromatin - DNA and proteins - plays a critical role.

During adolescence, the teen brain goes through dramatic changes which scientists are just beginning to better understand. For parents, teachers, and anyone who cares for a teenager—it is often ...

As I gradually cross the threshold from adolescence to adulthood, I often hear my peers joke that their prefrontal cortex is developing when they find themselves happily going to bed early on a Friday ...

Understanding how the brain learns and applies rules is the key to unraveling the neural basis of flexible behavior. A new study from the University of Toyama, Japan, reveals that our ability to ...