The AI-based program AlphaFold predicts a protein's 3D structure with remarkable accuracy. However, it tends to reduce heterogeneous structures to a single dominant conformation, or shape, and ...

Enzymes are regarded as the key to sustainable chemistry. Despite major advances in protein design, creating artificial enzymes from scratch has so far remained a grand challenge. A research team at ...

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

A joint research team has developed an automated design technology that enables the creation of DNA origami structures that ...

Beam-column connection in Reinforced Concrete (RC) frame is one of the most critical parts of the structure which has important role in seismic performance of these buildings. When a beam-column ...

The manuscript by Rotsides et al. reports the design and validation of SMART-MR1, a miniaturized MR1 metabolite-display platform in which the α1/α2 ligand-binding domain is stabilized by a synthetic ...

This fundamental work reveals that the accessibility of the unstructured C-terminal tails of α- and β-tubulins differs with the state of the microtubule lattice. Their accessibility increases with the ...

Seismic force-resisting systems (SFRS) are classified into three levels of inelastic response capability, designated as ordinary, intermediate or special, depending on the level of ductility that the ...

This article deals with prediction of buckling damage of steel equal angle structural members using a surrogate model combining machine learning and metaheuristic optimization technique. In particular ...

Natural products provide the inspiration for most drugs, and marine natural products, in particular, are emerging as promising new therapeutics with new targets or mechanisms of action.

Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a ...