Investopedia

Law of Diminishing Marginal Returns: Key Concepts and Examples

Adam Hayes, Ph.D., CFA, is a financial writer with 15+ years Wall Street experience as a derivatives trader. Besides his extensive derivative trading expertise, Adam is an expert in economics and ...
BMJ

Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis

Objectives Metabolic changes are crucially involved in osteoclast development and may contribute to bone degradation in rheumatoid arthritis (RA). The enzyme aconitate decarboxylase 1 (Acod1) is known ...
Nature

Early planetesimal differentiation and late accretion shaped Earth’s nitrogen budget

The relative roles of protoplanetary differentiation versus late accretion in establishing Earth’s life-essential volatile element inventory are being hotly debated. To address this issue, we employ ...
PNAS

Discovering optimal kinetic pathways for self-assembly using automatic differentiation

Self-assembly of protein subunits into macromolecular complexes is ubiquitous and essential for living systems. A common obstacle during self-assembly is the formation of kinetically trapped ...
Frontiers

Transcranial magnetic stimulation input–output curve slope differences suggest variation in recruitment across muscle representations in primary motor cortex

Measurement of the input–output (IO) curves of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) can be used to assess corticospinal excitability and motor recruitment ...
Nature

Bateman gradients from first principles

In 1948, Angus Bateman presented experiments and concepts that remain influential and debated in sexual selection. The Bateman gradient relates reproductive success to mate number, and Bateman ...
Quanta Magazine

Mathematicians Identify Threshold at Which Shapes Give Way

In the 1950s, four decades before he won a Nobel Prize for his contributions to game theory and his story inspired the book and film “A Beautiful Mind,” the mathematician John Nash proved one of the ...
C&EN

Improved Proteome and Phosphoproteome Analysis on a Cation Exchanger by a Combined Acid and Salt Gradient

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
C&EN

Water in Hydration Shell of an Iodide Ion: Structure and Dynamics of Solute-Water Hydrogen Bonds and Vibrational Spectral Diffusion from First-Principles Simulations

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
Frontiers

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

Studies on monocyte and macrophage biology and differentiation have revealed the pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue integrity by ...