Hackaday

HamsterOS Crams Complete Graphical Desktop Onto 1.44 MB Floppy

It’s not every day that there’s a new OS in the works for 386 and 486-era hardware, but [John Swiderski] let us know he ...
Frontiers

Using global datasets to estimate flood exposure at the city scale: an evaluation in Addis Ababa

Introduction: Cities located in lower income countries are global flood risk hotspots. Assessment and management of these risks forms a key part of global climate adaptation efforts. City scale flood ...
BMJ

Cost-effectiveness analysis of cetuximab combined with chemotherapy as a first-line treatment for patients with RAS wild-type metastatic colorectal cancer based on the TAILOR trial

Objectives Cetuximab plus leucovorin, fluorouracil and oxaliplatin (FOLFOX-4) is superior to FOLFOX-4 alone as a first-line treatment for patients with metastatic colorectal cancer with RAS wild-type ...
PNAS

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket

RAS is mutated in nearly 20% of human cancers and has few direct, efficacious inhibitors. Here, we developed a synthetic protein, JAM20, to discover potential regions on RAS that may be used for ...