Despite the advent of “methylomic” analyses, bisulfite modification of genomic DNA followed by Sanger sequencing remains the most precise assay for investigating the methylation profile of specific ...

This repo contains a PyTorch implementation for the paper "Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion". The training and sampling part of the code is inspired by Score ...

Trained on sequences of length 131k, with a model size of 256 and 16 layers. Trained for 50k steps and batch size of 8. Trained with reverse-complement (RC) data ...

DNA sequences of nearly any desired composition, length, and function can be synthesized to alter the biology of an organism for purposes ranging from the bioproduction of therapeutic compounds to ...

Genetic variants across the genome contribute to complex human diseases and agricultural traits, but interpreting them can be challenging. We propose a genome-wide variant effect prediction approach ...

The Brain and Muscle ARNTL-Like 1 protein (BMAL1) forms a heterodimer with either Circadian Locomotor Output Cycles Kaput (CLOCK) or Neuronal PAS domain protein 2 (NPAS2) to act as a master regulator ...

RNA hairpin structures require perfect pairing between consecutive bases of the opposite sides of the stem. Random mutations are unlikely to create complex structures, so the origin of long stems and ...

Herbal drug authentication is an important task in traditional medicine; however, it is challenged by the limitations of traditional authentication methods and the lack of trained experts. DNA ...