Plant immunity research has undergone a transformative shift with the advent of spatial and single-cell technologies, ...

Contributed by Howard Y. Chang; received November 19, 2024; accepted February 20, 2025; reviewed by Jellert Gaublomme and David A. Quigley The spatial organization of cells within tissues plays a ...

Discover why animal models fall short in AI drug discovery and how human-first datasets and functional genomics are changing ...

Spermatogenesis is a tightly regulated spatiotemporal process that generates mature spermatozoa in the testes, relying on the sequential differentiation of germ cells and coordinated interactions with ...

We developed a statistical method for Integrative and Reference-Informed Spatial Domain Detection for Spatial Transcriptomics. IRIS is a reference-informed integrative method for detecting spatial ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a spatial map of muscle-invasive bladder ...

Microplastics—minuscule pieces of plastic broken down from larger plastic waste—are a growing concern for human health, ...

Why do so many promising drugs fail? This article explores how spatial multiomics reveals hidden cell interactions, helping scientists identify stronger targets, predict outcomes earlier, and reshape ...

Among the assorted communities of brain cells contained within an 8 millimeter punch of cortex, scientists have captured what might reflect two pivotal microglial moments along the decades-long ...

Summary: Researchers unmasked a critical cellular transition that dictates whether Alzheimer’s disease pathology triggers clinical dementia. The research analyzed brain tissue from older adults, ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. The authors performed seqFISH in 26 gastruloids and performed a ...